Ation. J neurosci methods. 2011 oct 15;201(2):296-306. buy viagra Epub 2011 aug 17. Microscopic magnetic resonance elastography of traumatic brain injury model. Boulet t, kelso ml, othman sf. generic viagra canada Source department of engineering mechanics, w303 nebraska hall, university of nebraska-lincoln, lincoln, ne 68588, usa. Thomas. Boulet@huskers. Unl. Edu abstract traumatic brain injury (tbi) is a major cause of death and disability for which there is no cure. viagra reduced hamster jet lag One of the issues inhibiting clinical trial success is the lack of targeting specific patient populations due to inconsistencies between clinical diagnostic tools and underlying pathophysiology. viagra pills The development of reliable, noninvasive markers of tbi severity and injury mechanisms may better identify these populations, thereby improving clinical trial design. best viagra pills in pakistan Magnetic resonance elastography (mre), by assessing tissue mechanical properties, can potentially provide such marker. Mre synchronizes mechanical excitations with a phase contrast imaging pulse sequence to noninvasively register shear wave propagation, from which local values of tissue viscoelastic properties can be deduced. The working hypothesis of this study is that tbi involves a compression of brain tissue large enough to bring the material out of its elastic range, sufficiently altering mechanical properties to generate contrast on mre measurements. To test this hypothesis, we combined microscopic mre with brain tissue collected from adult male rats subjected to a controlled cortical impact injury. Measurements were made in different regions of interest (somatosensory cortex, hippocampus, and thalamus), and at different time points following the injury (immediate, 24 h, 7 days, 28 days). Values of stiffness in the somatosensory cortex were found to be 23-32% lower in the injured hemisphere than in the healthy one, when no significant difference was observed in the case of sham brains. A preliminary in vivo experiment is also presented, as well as alternatives to improve the faithfulness of stiffness recovery. best viagra pills in pakistan Copyright â© 2011 elsevier b. female viagra samples V. All rights reserved. viagra without prescription Pmid: 21871490 [pubmed - indexed for medline] publication types, mesh terms, grant support publication types research support, n. buy viagra online without script I. buy viagra online H. , extramural research support, non-u. S. is viagra safe to buy online Gov't mesh terms animals brain injuries/pathology brain injuries/physiopathology* disease models, animal elasticity imaging techniques/instrumentation elasticity imaging techniques/methods* hippocampus/injuries hippocampus/pathology hippocampus/physiopathology male mice mi.
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